CARDIAC ENZYMES AND POCT BIOMARKERS

Point of Care automatic analyzer for immunoassays

NEXUS IB10

Immunoassay analyzer for the analysis of the main cardiac enzymes and biomarkers

Nexus IB10 is an immunochemical platform for the dosage of biomarkers dedicated to the Point Of Care which provides the clinician with important results in just 20 minutes for the management of critically ill patients in intensive care, emergency rooms and specialist departments. In addition to cardiac enzyme, PCT and D-Dimer assays, IB10 offers new highly predictive markers for Sepsis, AKI, endothelial and multi-organ damage.

FEATURES

Fast and fully automatic

Up to 3 analytes in just 20 minutes. Fully automatic internal calibration.

Whole blood

No sample pre-treatment for plasma separation. Centrifugation takes place automatically within the system.

High quality results

Systematic control of all analysis steps. The rotor also includes internal positive QC to ensure that the system is running properly.

Simple and intuitive

Color touch screen with intuitive icons with step by step instructions.

Effective and ready to use

Rotors ready to use. One-step test execution.

High portability

Results can be printed directly via the on-board printer or sent to the LIS/HIS via WI-FI.

NEXUS IB10

WHEREVER YOU NEED

The internal rechargeable battery makes Nexus IB10 usable on all moving emergency vehicles such as helicopters and ambulances and in all emergency medical contexts.

NEXUS IB10 | OPERATING PROCEDURE

3 simple steps

Apply 500 µL of sample to the rotor well

Insert the rotor into the tool

Wait 20 minutes for results to print

SPHINGOTEC, A GERMAN BIOTECH COMPANY, AMONG WHICH FOUNDERS INCLUDE DR. ANDREAS BERGMANN – «FATHER» OF PROCALCITONA – HAS IDENTIFIED HIS MISSION IN THE REDUCTION OF THE MORTALITY OF CRITICAL PATIENTS IN INTENSIVE THERAPY.

NEXUS IB10

PENKID®| BIO ADM®| DPP3

Sphingotec’s effort introduced 3 new proprietary biomarkers for use in the ICU to diagnose, predict and monitor major mortality drivers such as sepsis, acute heart failure, loss of endothelial function, circulatory shock, and acute kidney injury (AKI), al in order to support the clinician in patient management and provide guidance for the induction and escalation of therapy.

IB10 SPHINGOTEST® PENKID®

penKid® quantitatively determines the stable fragment of the hormone enkephalin which stimulates renal function. The increase and decrease of penKid® values reveal worsening or improvement of renal function independent of inflammation or any other comorbidity.

penKid® allows prediction, diagnosis and monitoring of acute kidney injury (AKI) up to 2 days before serum creatinine.

benefits

Guide to the administration of nephrotoxic drugs

Guide to renal replacement therapy

Guide to renal replacement therapy

IB10 SPHINGOTEST® BIO-ADM®

Bioactive adrenomedullin is an endothelial barrier control hormone. Bio-ADM® measures the bioactive fraction released by endothelial cells verifying vascular integrity – very important for blood pressure control and organ perfusion. Quantitative measurement of Bio-ADM® in plasma provides timely information on decongestant treatment, in case of acute heart failure and administration of vasopressors in patients at risk of shock or septic shock

benefits

Anticipates the onset of septic shock up to 2 days

Guide to escalation or modification of antibiotic therapy

Predicts residual congestion in patients with acute heart failure

IB10 SPHINGOTEST® DPP3®

Dipeptidyl Peptidase 3 (DPP3) is an intracellular enzyme. In a diseased state, cell death results in the uncontrolled release of DPP3 which inactivates the angiotensin II and enkephalin systems resulting in short-term organ dysfunction.

Increasing levels of DPP3 in plasma indicate an elevated risk of hemodynamic instability associated with a high risk of mortality.

benefits

Guide for induction or escalation of therapy

Stratification of high-risk patients to develop short-term organ dysfunction

Monitoring of treatment success

NEXUS IB10

LARGE TEST PANEL

IB10 SPHINGOTEST® DPP3®

In addition to innovative biomarkers, the Nexus IB10 platform complements a wide range of diagnostic applications established in the routine of emergency departments.

IB10 sphingotest® PCT

For the quantitative determination of Procalcitonin (range 0.3 µg/L – 10µg/L)

IB10 sphingotest® Troponin-99

For the quantitative determination of Troponin I (cTnI)

IB10 sphingotest® NT-proBNP

For the quantitative determination of NT-proBNP

IB10 sphingotest® D-Dimer

For the quantitative determination of fibrin degradation products containing D-Dimer

IB10 sphingotest® Shortness of Breath

For the simultaneous quantitative determination of Troponin I (cTnI), NT-proBNP and D-Dimer

IB10 sphingotest® 3-in-1 Cardiac

For the simultaneous quantitative determination of Troponin I (cTnI), CK-MB and Myoglobin

IB10 sphingotest® TSH

For the quantitative determination of thyroid stimulating hormone (TSH

IB10 sphingotest® beta-hCG

For the quantitative determination of human chorionic gonadotropin (beta-hCG)